منابع مشابه
Suppression of miR-16 promotes tumor growth and metastasis through reversely regulating YAP1 in human cholangiocarcinoma
BACKGROUND & AIMS Aberrant expression of microRNAs is associated with many cancers progression. Many studies have shown that miR-16 is down-regulated in many cancers. However, its role in cholangiocarcinoma (CCA) is unknown. METHODS Quantitative real-time PCR (qRT-PCR) was developed to measure miR-16 expression in CCA tissues and cell lines. CCK-8, colony formation and transwell assays were u...
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Cancer cells that express oncogenic alleles of RAS typically require sustained expression of the mutant allele for survival, but the molecular basis of this oncogene dependency remains incompletely understood. To identify genes that can functionally substitute for oncogenic RAS, we systematically expressed 15,294 open reading frames in a human KRAS-dependent colon cancer cell line engineered to...
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By and large, gene expression levels in diploid organisms reflect the combined transcription of both copies, or alleles, of that gene. Notable exceptions include genes on the X chromosome and imprinted genes. The presence of genes in only one copy or in more than two copies can have major effects on the development and fitness of an organism. Many examples of these gene dosage effects can be fo...
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ژورنال
عنوان ژورنال: Molecular Cell
سال: 2007
ISSN: 1097-2765
DOI: 10.1016/j.molcel.2007.09.004